The basic story of Leonardo is that Leonardo is a young painter apprentice. While painting in a workshop in Florence,he meets Lisa. To be able to paint, she disguises herself as a boy, Tomaso. They have two other friends, Machiavelli and Lorenzo. Lorenzo's father, Piero de Medici tries to come up with plots to get rid of Leonardo and Tomaso without getting caught, including risking the lives of a couple of people.